It is a group of disorders of different aetiology in which lesions in the lungs produce a chest radiograph abnormality associated with an increase in the number of the eosinophil leucocytes in the peripheral blood.
- Exterinsic pulmonary eosinophilia.
- Intrinsic pulmonary eosinophilia.
[A] Extrinsic: (Know cause)
• Ascaris lumbricoids.
• Ankylostoma duodenale.
• Toxocara canis.
• Para-amino-salicylic acid.
3. Fungi- Aspergillus fumigates.
[B] Intrinsic: (unknown causes)
1. Cryptogenic eosinophilic pneumonia.
2. Churg-strauss syndrome.
3. Hypereosinophilic syndrome.
4. Polyarthritis nodosa (rare)
Pathophysiology: IgE mediated eosinophil production is induced by compounds released by basophils and mast cells, including eosinophil chemotactic factor of anaphylaxis, leukotriene B4, complement complex (C5-C6-C7), interleukin 5, and histamine (though this has a narrow range of concentration).
Treatment of pulmonary eosinophilia:
1. Symptomatic treatment: Antipyretic & bronchodilators etc.
2. Treatment of the cause:
a) Antihelminthic (if due to helminthes)
b) Withdraw of drug (if due to drugs)
c) Diethylcarbamazine (if due to microfilaria)
d) Prednisolone (if cryptogenic)
Complications of pulmonary eosinophilia:
- Bronchial asthma.
- Pleural effusion.
- Fibrosing alveolitis.
- Davidson’s Principles and Practice of Medicine, 21st edition.
- Wikipedia free encyclopedia.
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