The macrolides are a group of drugs (typically antibiotics) whose activity stems from the presence of a macrolide ring, a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. The lactone rings are usually 14-, 15-, or 16-membered. Macrolides belong to the polyketide class of natural products.
Name the Macrolides:
- Clarithromycin:Drug of chice of H.pylori.
Mechnism of action:
Macrolid binds with 50s ribosomal RNA
Prevent translocation reaction of bacteria
Inhibit protein synthesis
Indication of Macrolides/Erythromycin:
1) Whooping cough(Diptheria).
4) Non gonococcal urethritis/Syphilis/in pregnency & chidhood.
6) Respiratory tract infection.
7) Community acquired pneumonia.
8) Penicillin substitute in penicillin sensitivity.Prophylaxis against endocarditis.
Adverse effects of Erythromycin:
Contraindication of microlids:
Pregnancy=*Hepatic failure due to fatty change of liver.