The macrolides are a group of  drugs (typically antibiotics) whose activity stems from the presence of a macrolide ring, a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. The lactone rings are usually 14-, 15-, or 16-membered. Macrolides belong to the  polyketide class of  natural products.

Name the Macrolides:

  • Erythromycin:Antibiotic.
  • Azithromycin:Antibiotic.
  • Clarithromycin:Drug of chice of H.pylori.

Mechnism of action:

Macrolid binds with 50s ribosomal RNA

Prevent translocation reaction of bacteria

Inhibit protein synthesis

Indication of Macrolides/Erythromycin:

1)      Whooping cough(Diptheria).

2)      Pharyngitis.

3)      Tonsilitis.

4)      Non gonococcal urethritis/Syphilis/in pregnency & chidhood.

5)      Acne.


6)      Respiratory tract infection.

7)      Community acquired pneumonia.

8)      Penicillin substitute in penicillin sensitivity.Prophylaxis against endocarditis.


Adverse effects of Erythromycin:

1)      GIT:Nausea,Vomiting,Diarrhoea.

2)      Liver:Cholestatic,Jaundice.

Contraindication of microlids:

Pregnancy=*Hepatic failure due to fatty change of liver.


*Teratogenic effect.

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