Gentamicin

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Gentamicin:It is a member of aminoglycoside isolated from Micromonospora purpurea.It is effective against both gm +ve & gm –ve organism.

Mechanism of action

Gentamicin is a bactericidal antibiotic that works by irreversibly binding the 30S subunit of the bacterial ribosome, interrupting protein synthesis. This mechanism of action is similar to other Aminoglycosides

Indications:

1)      Infection with pseudomonas,proteus, enterobacter, klebsiella etc.

2)      Gentamicin + Penicillin G→in subacute endocarditis by S.Viridance & enterococci.

3)      Gentamicin + Nafcillin→in staph endocarditis.

4)      Meningitis caused by gm(-ve) bacteria.

 

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5)      Serious gm(-)ve septicemia.

6)      Abdominal & pelvic sepsis.

7)      In case of surgical procedure.

Adverse effects:

1)      Nephrotoxicity.

2)      Ototxicity.

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