Furosemide (INN/BAN) or frusemide (former BAN) is a loop diuretic used in the treatment of congestive heart failure and edema. It is most commonly marketed by Sanofi under the brand name Lasix, and also under the brand names Fusid and Frumex. It has also been used to prevent Thoroughbred and Standardbred race horses from bleeding through the nose during races.
Along with some other diuretics, furosemide is also included on the World Anti-Doping Agency’s banned drug list due to its alleged use as a masking agent for other drugs.
[A]Frusemide inhibits the Na^+ -K^(+ )transport system in the thick ascending limb of loop of henle.
↓Reabsorption of Na^+,K^+ & Cl^-
↑Excretion of these ions with iso-osmotic amount of water(Diuresis).
[B]Inhibits Ca^(++),Mg^(++) reabsorption→let them be excreted with iso-osmotic amount of water(diuresis).
[C]↑Renal blood flow & causes redistribution of blood flow with in the renal cortex→↑ GFR & urine formation.
Drug poisoning (due to force diuresis).
Acute pulmonary oedema & other edematous condition.
Hyperkalemia & hypercalcemia.
Acute renal failure.
Volume depletion causing hypotension.
Hyperurecemia(may leads to gout).
Ototoxicity(loss of hearing).