Xanthine derivatives – Amylophyllin

  Mechanism of action: [A]Amynophyllin→Inhibits Phosphodiesterase enzyme→No conversion of cAMP to 5-AMP→↑cAMP→Relaxation of bronchial smooth mucle→Bronchodilation→Relief of asthma. [B]Amynophyllin→Inhibits presynaptic adenosine receptor of brochus→↑Catecholamine release→Bronchodilation. Advantages: 1)      Rapid onset of action. 2)      Suitable for acute[…]

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